Gynecologic Oncology Group (GOG) Trials

Title Protocol IDs Phase
Ovarian Cancer (non-sarcoma)
A randomized phase III trial comparing first-line intraperitoneal (IP) chemotherapy versus first-line intravenous (IV) chemotherapy (all patients get study supplied bevacizumab) GOG 252 Phase III
A randomized phase III trial comparing observation versus maintenance chemotherapy among those in remission after first-line chemotherapy GOG 212 Phase III
A randomized phase III trial comparing secondary debulking surgery versus no surgery and comparing chemotherapy with bevacizumab versus chemotherapy without bevacizumab among those who fail first-line chemotherapy GOG 213 Phase III
A phase II randomized, double-blind trial of a polyvalent vaccine-KLH conjugate (NSC 748933 IND# 14384) + opt-821 versus opt-821 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer who are in second or third complete remission GOG 255 Phase II
A Phase II Evaluation of Elesclomol Sodium and Weekly Paclitaxel in the Treatment of Recurrent or Persistent Platinum-Resistant Ovarian,Fallopian Tube or Primary Peritoneal Cancer (IND 110072) GOG 260 Phase II
A Randomized Phase III Trial of Every-3-Weeks Paclitaxel versus Dose Dense Weekly Paclitaxel in Combination with Carboplatin with or without Concurrent and Consolidation Bevacizumab (NSC #704865, IND #7921) in the Treatment of Primary Stage III or IV Epitelial Ovarian, Peritoneal or Fallopian Tube Cancer GOG 262 Phase III
Uterine (endometrial) Cancer
A Randomized, Controlled Phase II Evaluation of Megestrol in Different Dose and Sequence in the Treatment of Endometrial Intraepithelial Neoplasia (EIN) From A Referred Cohort of Atypical Endometrial Hyperplasia (AEH) or EIN
 GOG 224 Phase II
A randomized phase III trial comparing pelvic radiation therapy versus vaginal radiation implants followed by chemotherapy among those with high Risk, early stage disease (node negative GOG 249
 Phase III
A randomized phase III trial comparing radiation therapy with chemotherapy versus chemotherapy alone among those with advanced/metastatic disease GOG 258 Phase III
A study evaluating the utility or "x-rays" (FDG-PET/CT scanning) among those with newly diagnosed high risk tumors GOG 233 Phase II
A randomized trial comparing pelvic Irradiation versus pelvic Irradiation with concurrent chemotherapy among those with pelvic-only recurrent cancer GOG 238 Phase II
A three arm randomized phase II study of three chemotherapy regimens containing novel and/or biological as front-line therapy for "measurable" stage III or IVA, stage IVB, or recurrent cancer GOG 86P Phase II
Cervical Cancer
A randomized phase III trial of pelvic radiation versus pelvic radiation with chemotherapy among those with intermediate risk, early stage cancer (negative nodes) treated with initial surgery GOG 263 Phase III
A randomized phase III trial of pelvic radiation with chemotherapy versus pelvic radiation with chemotherapy followed by additional doses of chemotherapy among those with high risk, early stage cancer (positive nodes) treated with initial surgery GOG 0724 Phase III
A study evaluating the utility or "x-rays" (FDG-PET/CT scanning) versus surgical staging prior to pelvic radiation with chemotherapy among those with locally advanced tumors (stage IB2-IVA) GOG 233 Phase I
A randomized phase III trial comparing two chemotherapy doublets and comparing chemotherapy with bevacizumab to chemotherapy without bevacizumab among those who fail first-line treatment or who have newly diagnosed metastatic cancer (stage IVB) GOG 240 Phase III
Other: Including Gestational Trophoblastic Disease, Rare Tumors and Sarcomas
A GCIG Intergroup Mulitcenter Phase III Trial of Open Label Carboplatin and Paclitaxel +/- Bevacizumab Compared with Oxaliplatin and Capecitabine +/- Bevacizumab as First Line Chemotherapy in Patients with Mucinous Epithelial Ovarian Cancer GOG 241 Phase III
A phase II study to determine the efficacy of a second "D&C" as initial management of low risk gestational trophoblastic disease GOG 242 Phase II
A phase II evaluation of SU11248 (Sunitinib Malate)in the treatment of persistent of recurrent clear cell ovarian cancer GOG 254 Phase II
A randomized phase II trial of two chemotherapy combinations among those newly diagnosed advanced or recurrent sex cord-stromal tumors of the ovary GOG 264 Phase II
A randomized phase III trial of chemotherapy versus chemotherapy plus bevacizumab in the treatment of recurrent or advanced uterine leiomyosarcoma GOG 250 Phase III
A randomized phase III trial of two chemotherapy combinations among those with newly diagnosed or recurrent carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus or Ovary GOG 261

Phase III

A Phase II Evaluation of Temsirolimus (CCI-779) (NCI Supplied Agent: 683864, IND #61010)in Combination with Carboplatin and Paclitaxel followed by Temsirolimus Consolidation as First-line Therapy in the Treatment of Clear Cell Carcinoma of the Ovary. GOG 268
 Phase II